Zhi Shi Li Zhong Wan

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枳实理中丸 (Unripe Bitter Orange Pill to Regulate the Middle)

Source: Formulary of the Pharmacy Service for Benefiting the People in the Taiping Era (1148)

Last updated October 1, 2026

Not yet clinically reviewed

Description

Zhi Shi Li Zhong Wan (Unripe Bitter Orange Pill to Regulate the Middle), from Formulary of the Pharmacy Service for Benefiting the People in the Taiping Era (1148).

Associated formula of Li Zhong Wan.

Actions: Strengthens the Spleen; Warms the middle; Dissipates clumps

Indications: Spleen and Stomach deficiency cold with clumping: abdominal fullness, distention, and pain.

Usage: For middle-burner deficiency cold complicated by clumping and distention.

Category: Formulas that Warm the Middle and Dispel Cold.

Source: Scheid V, Bensky D, Ellis A, Barolet R. Chinese Herbal Medicine: Formulas & Strategies, 2nd ed. Eastland Press, 2009, p. 261.

Composition

Herb Amount % Role Function
Zhi Shi
as printed: Aurantii Fructus immaturus (zhi shi) 30g
30g 9.09% —
Gan Jiang
as printed: Zingiberis Rhizoma (gan jiang) 60g
60g 18.18% —
Ren Shen
as printed: Ginseng Radix (ren shen) 60g
60g 18.18% —
Bai Zhu
as printed: Atractylodis macrocephalae Rhizoma (bai zhu) 60g
60g 18.18% —
Fu Ling
as printed: Poria (fu ling) 60g
60g 18.18% —
Gan Cao
as printed: Glycyrrhizae Radix preparata (zhi gan cao) 60g
60g 18.18% —

Energetics dose-weighted

The formula's overall nature, taste balance and channel reach, weighted by each herb's dose. Classical formulas often pair warm and cool herbs on purpose, so a net figure summarises the mix — it doesn't describe every herb in it.

Nature

Cold Cool Neutral Warm Hot

Net slightly warm (+0.64)

From 100% of the weighed grams.

cool neutral warm hot

Grams by band: cool 9%, neutral 36%, warm 36%, hot 18%.

Taste

pungent sweet sour bitter bland
  • pungent 21%
  • sweet 46%
  • sour 3%
  • bitter 21%
  • bland 9%

From 100% of the weighed grams.

Channels reached

  • Spleen 100%
  • Lung 73%
  • Heart 73%
  • Stomach 64%
  • Kidney 36%
  • Large intestine 9%

Share of the grams entering each channel, from 100% of the weighed grams.

Dose-weighted from each herb's recorded nature, taste and channels (missing values are left out, never counted as neutral). It describes the composition — it is not a recommendation.

Compare side by side with Gun Tan Wan →

Preparation

Powder formed into yolk-sized (3-6g) honey pills taken with hot water.

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Formula family

Each entry reads as the larger formula written out: “+” adds its other catalogue cores, then the herbs none of them hold. A catalogue formula counts as a core only when at least 80% of its herbs are present, no more than 1 is absent, and the absent herb is not its chief.

Formula Network

Formulas that share herbs with this one — the closer to the centre, the stronger the match. Click a node to explore.

Similar Formulas by composition

Match score combines dosage-weighted composition (cosine, 70%) with shared-herb overlap (Jaccard, 30%).

Traditional formula information is for educational purposes only. Herbal formulas should be prescribed by a qualified practitioner — dosages and combinations are individualized and can interact with medications.

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