Li Zhong Wan

Star

理中丸 (Regulate the Middle Pill)

Source: Shang Han Lun (c. 220)

Last updated October 1, 2026

Not yet clinically reviewed

internal cold due to Spleen-Yang deficiency

Description

Li Zhong Wan (Regulate the Middle Pill), from the Shang Han Lun, is used to warm the Middle-Jiao; strengthen the Spleen-Yang.

Presentation: internal cold due to Spleen-Yang deficiency.

Syndrome: Internal cold syndrome.

Composition strategy:

  • each herb group represents one aspect of rebuilding Middle-Jiao Yang
  • honey pill form builds Yang steadily; suited to chronic Spleen-Yang deficiency

Source: Yang Y. Chinese Herbal Formulas: Treatment Principles and Composition Strategies. Churchill Livingstone Elsevier, 2010, p. 124, 183.

Composition

Herb Amount % Role Function
Ren Shen
as printed: Ren Shen (Ginseng radix)
6g 23.08% Jun (Chief) strongly tonify Spleen-Qi
Gan Jiang
as printed: Gan Jiang (Zingiberis rhizoma)
5g 19.23% Jun (Chief) quickly warm the Middle-Jiao
Bai Zhu
as printed: Bai Zhu (Atractylodis macrocephalae rhizoma)
9g 34.62% Chen (Deputy) tonify Spleen-Qi, dry dampness from Yang deficiency
Gan Cao
assistant and envoy; as printed: Zhi Gan Cao (Glycyrrhizae radix preparata)
6g 23.08% Zuo (Assistant) tonify Spleen, harmonize and moderate

Dui Yao — Core Herb Pairs

The classical two-herb combinations at the heart of this formula, as recorded on the herbs' own pages — each pair has an action neither herb has alone.

Gan Jiang干姜 + Ren Shen人参

The middle burner is warmed and cold dispelled while spleen qi is tonified, treating deficiency cold of spleen and stomach.

Energetics dose-weighted

The formula's overall nature, taste balance and channel reach, weighted by each herb's dose. Classical formulas often pair warm and cool herbs on purpose, so a net figure summarises the mix — it doesn't describe every herb in it.

Nature

Cold Cool Neutral Warm Hot

Net warm (+0.96)

From 100% of the weighed grams.

neutral warm hot

Grams by band: neutral 23%, warm 58%, hot 19%.

Taste

pungent sweet bitter
  • pungent 19%
  • sweet 52%
  • bitter 29%

From 100% of the weighed grams.

Channels reached

  • Spleen 100%
  • Stomach 77%
  • Lung 65%
  • Heart 65%
  • Kidney 23%

Share of the grams entering each channel, from 100% of the weighed grams.

Dose-weighted from each herb's recorded nature, taste and channels (missing values are left out, never counted as neutral). It describes the composition — it is not a recommendation.

Compare side by side with Liu Shen San →

Preparation

pill made with honey

Click a node for details · double-click to expand it · Ctrl/⌘ + scroll or two fingers to zoom and pan.

Loading graph…

Formula family

Each entry reads as the larger formula written out: “+” adds its other catalogue cores, then the herbs none of them hold. A catalogue formula counts as a core only when at least 80% of its herbs are present, no more than 1 is absent, and the absent herb is not its chief.

Formula Network

Formulas that share herbs with this one — the closer to the centre, the stronger the match. Click a node to explore.

Similar Formulas by composition

Match score combines dosage-weighted composition (cosine, 70%) with shared-herb overlap (Jaccard, 30%).

Traditional formula information is for educational purposes only. Herbal formulas should be prescribed by a qualified practitioner — dosages and combinations are individualized and can interact with medications.

📝 Notes

Public notes from the community and your own private notes on Li Zhong Wan.

No notes yet.

Log in or register to add your own notes.

Back to Formula Library