Zhi Gan Cao Tang

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炙甘草汤 (Radix Glycyrrhizae Uralensis Decoction)

Source: Shang Han Lun (c. 220)

Last updated October 1, 2026

Not yet clinically reviewed

chronic palpitationsirregular pulseHeart-Qi deficiency with blood, Yin and Yang deficiency

Description

Zhi Gan Cao Tang (Radix Glycyrrhizae Uralensis Decoction), from the Shang Han Lun, is used to tonify the Heart-Qi; nourish blood and Yin; stimulate Heart-Yang; relieve palpitations.

Presentation: chronic palpitations; irregular pulse; Heart-Qi deficiency with blood, Yin and Yang deficiency; pulse: irregular.

Syndrome: Syndrome of Heart-Qi deficiency.

Composition strategy:

  • treats chronic palpitations by tonifying and stabilizing the Qi-blood and Yin-Yang relationships, addressing both Qi function and its material base (Yin and blood)

Cautions:

  • Yang-stimulating herbs should be in small dosage as they consume Qi and Yin
  • with obvious Yin deficiency (red tongue without coating, thready rapid pulse) the warm-pungent herbs should not be used

Source: Yang Y. Chinese Herbal Formulas: Treatment Principles and Composition Strategies. Churchill Livingstone Elsevier, 2010, p. 146.

Composition

Herb Amount % Role Function
Gan Cao
as printed: Zhi Gan Cao (Glycyrrhizae radix preparata)
12g 13.19% Jun (Chief) directly tonify Heart-Qi
Ren Shen
as printed: Ren Shen (Ginseng radix)
6g 6.59% Jun (Chief) directly tonify Heart-Qi
Da Zao
dose printed as 5–10 pieces; as printed: Da Zao (Jujubae fructus)
pieces — Jun (Chief) directly tonify Heart-Qi
Sheng Di Huang
as printed: Sheng Di Huang (Rehmanniae radix)
30g 32.97% Chen (Deputy) tonify blood, nourish Yin to house the Qi
Mai Men Dong
as printed: Mai Men Dong (Ophiopogonis radix)
10g 10.99% Chen (Deputy) tonify blood, nourish Yin
E Jiao
as printed: E Jiao (Asini corii colla)
6g 6.59% Chen (Deputy) tonify blood, nourish Yin
Huo Ma Ren
replaces Yang's Hei Zhi Ma; Chen and Qiao (and the Shang Han Lun formula) use Ma Ren
9g 9.89% Chen (Deputy) nourishes Yin and blood, moistens dryness
Sheng Jiang
as printed: Sheng Jiang (Zingiberis rhizoma recens)
9g 9.89% Zuo (Assistant) stimulate Heart-Yang, move Qi and blood
Gui Zhi
as printed: Gui Zhi (Cinnamomi cassiae ramulus)
9g 9.89% Zuo (Assistant) stimulate Heart-Yang, move Qi and blood

Energetics dose-weighted

The formula's overall nature, taste balance and channel reach, weighted by each herb's dose. Classical formulas often pair warm and cool herbs on purpose, so a net figure summarises the mix — it doesn't describe every herb in it.

Nature

Cold Cool Neutral Warm Hot

Net nature not shown: the chief herb (Da Zao) has no dose in grams.

From 100% of the weighed grams.

cold neutral warm

Grams by band: cold 44%, neutral 30%, warm 26%.

Pairs warm and cool. 26% of the weighed grams are warm or hot and 44% cool or cold — the net is their average, not the whole story.

Taste

pungent sweet bitter
  • pungent 15%
  • sweet 60%
  • bitter 25%

From 100% of the weighed grams.

Channels reached

  • Heart 74%
  • Lung 57%
  • Spleen 51%
  • Kidney 46%
  • Stomach 44%
  • Liver 40%

Share of the grams entering each channel, from 100% of the weighed grams.

1 herb without a dose in grams, so left out of every figure above: Da Zao.

Dose-weighted from each herb's recorded nature, taste and channels (missing values are left out, never counted as neutral). It describes the composition — it is not a recommendation.

Compare side by side with Liu Shen San →

Preparation

Source: cook in about 1 liter of liquid (7/15 rice wine, 8/15 water); now decocted with 10ml rice wine added at the end. Divide into three doses per day. Today half the sheng di dose and only 5-10 jujube are used; Codonopsis often replaces Ginseng at 2-3 times the dose.

Source: Scheid V, Bensky D, Ellis A, Barolet R. Chinese Herbal Medicine: Formulas & Strategies, 2nd ed. Eastland Press, 2009, p. 356.

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Formula family

Each entry reads as the larger formula written out: “+” adds its other catalogue cores, then the herbs none of them hold. A catalogue formula counts as a core only when at least 80% of its herbs are present, no more than 1 is absent, and the absent herb is not its chief.

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Similar Formulas by composition

Match score combines dosage-weighted composition (cosine, 70%) with shared-herb overlap (Jaccard, 30%).

Traditional formula information is for educational purposes only. Herbal formulas should be prescribed by a qualified practitioner — dosages and combinations are individualized and can interact with medications.

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