Yi Guan Jian

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一贯煎 (Linking Decoction)

Source: Xu Ming Yi Lei An (in Liu Zhou Yi Hua) — Wei Zhi-Xiu (1770)

Last updated October 1, 2026

Not yet clinically reviewed

atrophic gastritischronic gastritisgastric and duodenal ulcersgastric neurosispremenstrual syndromeovarian dysfunctiongestational hypertensionhepatitisliver cirrhosisliver cancerhypochondriac neuralgiahyperthyroidismrestless leg syndrome

Description

Yi Guan Jian (Linking Decoction), from the Xu Ming Yi Lei An (in Liu Zhou Yi Hua) (Continuation of Famous Physicians' Patients Organized by Categories (Medical Dialogues from Liuzhou)) by Wei Zhi-Xiu.

Actions: Nourishes Kidney and Liver yin; Regulates Liver qi.

Presentation: Liver and Kidney yin deficiencies accompanied by qi stagnation and blood dryness: pain in the chest, epigastric and hypochondriac regions, acid regurgitation, a sore throat, a dry mouth, a red tongue body with little moisture, and a pulse that is fine and weak or deficient and wiry. Occasionally, there may also be a hernia or mass.

Cautions:

  • Contraindicated for hypochondriac pain from Liver fire without underlying deficiency
  • Inappropriate for qi and blood stagnation or phlegm accumulation, as the tonics may worsen stagnation, dampness and phlegm

Toxicology: No abnormal reaction after a 50 g/kg oral bolus in mice.

Pharmacological effects reported:

  • Hepatoprotective: reduced CCl4 liver damage in mice
  • Antiulcer: marked effect on gastric and duodenal ulcers in mice by enhancing mucosal protection, not by neutralizing acid
  • Adaptogenic: 7 days increased physical performance in mice

Source: Chen JK, Chen TT. Chinese Herbal Formulas and Applications: Pharmacological Effects & Clinical Research. Art of Medicine Press, 2009, p. 657.

Composition

Herb Amount % Role Function
Sheng Di Huang
as printed: Di Huang (Radix Rehmanniae) 18-45 [30g]
30g 38.96% Jun (Chief) tonifies Liver and Kidney yin, nourishes blood
Bei Sha Shen
as printed: Bei Sha Shen (Radix Glehniae) 9g [10g]
10g 12.99% Chen (Deputy) tonifies yin, generates fluids, softens Liver
Mai Men Dong
as printed: Mai Dong (Radix Ophiopogonis) 9g [10g]
10g 12.99% Chen (Deputy) tonifies yin, generates fluids, softens Liver
Dang Gui
as printed: Dang Gui (Radix Angelicae Sinensis) 9g [10g]
10g 12.99% Chen (Deputy) nourishes blood, softens Liver
Gou Qi Zi
as printed: Gou Qi Zi (Fructus Lycii) 9-18g [12g]
12g 15.58% Chen (Deputy) tonifies yin, nourishes blood, softens Liver
Chuan Lian Zi
serves as both assistant and envoy; small dose because bitter-cold may consume yin; as printed: Chuan Lian Zi (Fructus Toosendan) 4.5g [5g]
5g 6.49% Zuo (Assistant) smoothes Liver qi, relieves pain, guides to Liver channel

Energetics dose-weighted

The formula's overall nature, taste balance and channel reach, weighted by each herb's dose. Classical formulas often pair warm and cool herbs on purpose, so a net figure summarises the mix — it doesn't describe every herb in it.

Nature

Cold Cool Neutral Warm Hot

Net cool (-1.17)

From 100% of the weighed grams.

cold cool neutral warm

Grams by band: cold 58%, cool 13%, neutral 16%, warm 13%.

Small but decisive: Chuan Lian Zi 5g (cold, 7% of the grams). Dose weighting nearly cancels a herb this small, but it may be what the formula is for.

Taste

pungent sweet bitter
  • pungent 7%
  • sweet 55%
  • bitter 39%

From 100% of the weighed grams.

Channels reached

  • Liver 74%
  • Heart 65%
  • Kidney 55%
  • Lung 42%
  • Stomach 26%
  • Spleen 26%

Share of the grams entering each channel, from 100% of the weighed grams.

Dose-weighted from each herb's recorded nature, taste and channels (missing values are left out, never counted as neutral). It describes the composition — it is not a recommendation.

Compare side by side with Liu Shen San →

Preparation

Warm strained decoction; today decoct with bracketed doses.

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Match score combines dosage-weighted composition (cosine, 70%) with shared-herb overlap (Jaccard, 30%).

Traditional formula information is for educational purposes only. Herbal formulas should be prescribed by a qualified practitioner — dosages and combinations are individualized and can interact with medications.

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