Long Chi

Star

Fossilia Dentis Mastodi

Not yet clinically reviewed

Genus: Fossilia Pinyin: Long Chi
Dragon Tooth Fossil龙齿

Traditionally used for

  • Dizziness
  • Sleep
  • Mood & calm
  • Nerves & recovery
  • Heart & circulation
Strong evidence · 2 studies

☯ TCM Properties

Category: calming spirit
Temperature: cool
Taste: sweet
Meridians: heart, liver
Functions:

Calms the Spirit and Settles Fright; Clears Heat and Eliminates Irritability; Calms the Liver and Subdues Yang

Traditional Chinese Uses

Long Chi (fossilized teeth, dragon's teeth) is a heavy, cool substance used in Chinese medicine to calm the Spirit, settle palpitations, and anchor Yang. Similar to Long Gu (dragon bone), it addresses anxiety, insomnia with disturbing dreams, and restlessness from Heart-Shen disturbance. Its Liver-calming properties also extend to dizziness and convulsions from Liver Yang rising or Liver Wind. The fossilized animal origin of this substance gives it its traditional "anchoring" and weight-settling properties.

Used In Formulas (2)

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Botanical Description

Long Chi (Fossilia Dentis Mastodi) is not a plant material but the fossilised teeth of various large Pleistocene mammals, principally extinct proboscideans such as mastodons and stegodonts, and to a lesser extent fossil teeth of rhinoceroses, deer, and oxen. The medicinal material consists of hard, dense, mineralised tooth fragments and crowns recovered from sedimentary deposits in central and northern China, often together with the related fossil bone material Long Gu. Pieces are heavy, mottled greyish-white, blue-grey, or brownish, with visible enamel ridges and a porcelain-like lustre on fractured surfaces. They are composed largely of fluorapatite and calcium carbonate. Pieces are sorted, brushed clean, and calcined or used raw after crushing.

Active Constituents

Fossilised enamel apatite

Calcium phosphate mineral, biogenic enamel apatite

Concentration: Enamel is the most highly mineralised tissue in the vertebrate body and survives fossilisation as the densest phase of the drug

The glossy, porcelain-like surface layer used to identify authentic Long Chi is fossilised tooth enamel. Its density is what distinguishes the drug from Long Gu, which is porous fossil bone, and the two-layer appearance of a cut surface with a visible fossilised pulp cavity is the standard pharmacognostic marker.

Fossilised dentine and secondary calcite infill

Carbonated hydroxyapatite with diagenetic calcium carbonate

Concentration: The bulk of the tooth beneath the enamel, plus calcite deposited into the pulp cavity and dentinal tubules during burial

Dentine is more porous than enamel and takes up more groundwater mineral during fossilisation. It is the fraction responsible for the hygroscopicity used in the traditional tongue-adhesion test, and the reason a calcium assay alone cannot authenticate the drug.

Fluoride substituted into the apatite lattice

Halide, lattice substituent

Concentration: Elevated relative to modern teeth, and higher again in older fossil material

Buried apatite exchanges hydroxide for fluoride from groundwater over geological time, the basis of fluorine dating in palaeontology. Fossil teeth therefore carry a fluoride load that fresh bone or tooth substitutes do not, which matters for a drug taken in gram quantities over months for insomnia and palpitations. The same problem afflicts Long Gu, where fluoride-rich fossil adulterants are documented.

Iron and manganese oxide staining

Diagenetic metal oxides

Concentration: Variable surface and internal staining acquired during burial

Groundwater iron and manganese give the drug its commercial grades: blue-grey to dark brown material is sold as Qing Long Chi and yellowish-white material as Bai Long Chi. The distinction is geochemical, a record of the burial environment rather than of any difference in the animal or in pharmacological activity.

Trace elements zinc and strontium

Trace metal authentication signature

Concentration: Characteristic of genuine fossil bioapatite rather than of modern bone

Strontium and zinc substitute into the apatite lattice during fossilisation and provide a geochemical fingerprint that distinguishes fossil material from processed contemporary bone. Their role is forensic rather than therapeutic.

⚠ Drug Interactions

Tetracyclines and fluoroquinolone antibiotics

Moderate Evidence: Probable

Long Chi is a calcium phosphate mineral taken in gram quantities. Divalent calcium chelates tetracyclines and fluoroquinolones in the gut lumen and substantially reduces their bioavailability, an established interaction for calcium salts and antacids. The extrapolation to fossil apatite is by chemistry rather than by a trial of this drug, and the solubilised calcium fraction from fossil enamel has not been measured.

Clinical note: Separate the herb from the antibiotic by at least two hours, or suspend it for the course.

Levothyroxine, oral bisphosphonates and oral iron

Moderate Evidence: Possible

Divalent-cation chelation of the same kind that makes calcium supplements interfere with levothyroxine, alendronate and ferrous salts applies in principle to a gram-scale calcium mineral. Evidence is by class analogy with calcium carbonate rather than by direct study of Long Chi.

Clinical note: Dose the conventional drug on an empty stomach well separated from the decoction, and recheck thyroid function if a stable levothyroxine dose starts to underperform.

Long Gu, processed modern animal bone and unauthenticated fossil sold as Long Chi

Major Evidence: Probable

Long Chi and Long Gu come from the same depleted deposits and are separated only by morphology, so substitution between them and with processed contemporary bone is easy and commercially attractive. Market studies of both drugs found material spanning nine mammalian families, and the wider fossil-drug market is documented as saturated with adulterants including fluoride-rich dinosaur fossils. A calcium-content specification is passed by every one of these.

Clinical note: Require material showing the characteristic enamel sheen, a hard dense two-layer cut surface with a visible pulp cavity, and strong tongue adhesion. A certificate of calcium content is not authentication.

Evidence Tier

Strong evidence · 2 studies

Recorded studies by study design, strongest design at the top. This is a study-design tier only, not a GRADE rating: it does not weigh risk of bias, consistency or precision.

Systematic review / meta-analysis

1

1 verified · 0 unverified

Show the study

Randomized controlled trial

0

Other clinical trial

0

Observational / case report

0

Other / unclassified

0

Verified: design read from PubMed for a DOI that resolves to the cited paper Unverified: taken from the study's recorded description

Clinical Studies

Taxonomic examination of longgu (Fossilia Ossis Mastodi, “dragon bone”) and a related crude drug, longchi (Dens Draconis, “dragon tooth”), from Japanese and Chinese crude drug markets

Oguri K, Nishioka Y, Kobayashi Y, Takahashi K (2017) Journal of Natural Medicines in vitro

Pharmacognostic and palaeontological identification study, not a clinical trial, and the only published examination of what market longchi and longgu actually are. Of 20,939 fossil fragments held by the Museum of Osaka University, 20,886 were mammalian and 246 could be assigned, falling into nine families; Japanese-market material spanned fewer taxa than Chinese-market material. The authors record that Chinese fossil resources are being depleted and propose bone from closely related contemporary animals as a substitute, arguing that the drug's effect appears independent of the precise source taxon.

Long Gu (Os Draconis): Textual research, modern scientific evaluation, and quality control challenges

Xiujia S, Zhan Hua L, Yuanze G, Ganesan K, Jing L, Li L, Chao Z, Chen J (2026) Journal of Ethnopharmacology systematic review Verified: Systematic review / meta-analysis

Systematic review of the sister drug Long Gu, included here because Long Chi shares its deposits, its market and its quality-control failure. It confirms authentic material as carbonated hydroxyapatite with a zinc-strontium trace profile, documents market saturation with fluoride-rich dinosaur fossils and processed modern bone, attributes this to resource exhaustion plus a pharmacopoeial standard that assays calcium alone, and calls the resource endangered.

⚠ Safety & Contraindications

Contraindications

It is not suited to combine with Gypsum Fibrosum ( shi gao ), Resina Toxicodendri ( gan qi ) or Pericarpium Zanthoxyli ( hua jiao ).

Source: Xi S, Gong Y. Essentials of Chinese Materia Medica and Medical Formulas. Academic Press/Elsevier, 2017, pp. 295–297.

Historical Texts

Shen Nong Ben Cao Jing

Han dynasty, compiled c. 200 CE
Long chi is recorded within the long gu entry with its own indication for fright epilepsy in children and adults, the distinction that has kept it a separate drug ever since. Its identity there is mythological: the teeth of dragons.

Ben Cao Gang Mu (Li Shizhen)

Ming dynasty, 1596
Li Shizhen's identification of the dragon bones as fossilised remains of ancient animals applies equally to the teeth, and marks the point at which the drug's origin became a palaeontological question. Modern market examination confirms mammalian fossil material from at least nine families.

Clinical convention distinguishing Long Chi from Long Gu

Song dynasty onward, and current
Long Chi is used preferentially for fright, palpitation and disturbed sleep and Long Gu for anchoring yang and astringing leakage, though the two are mineralogically almost the same material from the same deposits. The distinction is clinical tradition, not chemistry.

References

  1. Oguri K, Nishioka Y, Kobayashi Y, Takahashi K. Taxonomic examination of longgu (Fossilia Ossis Mastodi, “dragon bone”) and a related crude drug, longchi (Dens Draconis, “dragon tooth”), from Japanese and Chinese crude drug markets . Journal of Natural Medicines (2017) [DOI]
  2. Xiujia S, Zhan Hua L, Yuanze G, Ganesan K, Jing L, Li L, Chao Z, Chen J. Long Gu (Os Draconis): Textual research, modern scientific evaluation, and quality control challenges . Journal of Ethnopharmacology (2026) [DOI]

This information is for educational purposes only and is not intended to replace professional medical advice. Always consult a qualified healthcare provider before using any herbal remedy, especially if you are pregnant, nursing, or taking medications.

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