An Shen Wan

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朱砂安神丸 (Pill to Calm the Shen)

Source: Yi Xue Fa Ming (1247)

Last updated October 1, 2026

Not yet clinically reviewed

acute anxiety from sudden uprising of Heart-fire

Description

An Shen Wan (Pill to Calm the Shen), from the Yi Xue Fa Ming, is used to directly descend Heart-fire and sedate the Heart-shen; nourish Heart-Yin injured by excess fire.

Presentation: acute anxiety from sudden uprising of Heart-fire.

Syndrome: Syndrome of disturbance of Heart-shen.

Composition strategy:

  • all ingredients enter the Heart meridian
  • a strong mineral descends fire, removes fire-toxin and sedates the Shen
  • herbs reducing excess and empty fire of the Heart calm the mind
  • large dose of Zhi Gan Cao smooths Qi and moderates circulation to reduce tension
  • Yin and blood status is also addressed

Cautions:

  • short-term use only
  • Zhu Sha must be water-ground and used only as a very thin pill coating; its use is now forbidden - substitute Long Chi, Zhen Zhu and Huang Lian (weaker, slower)

Source: Yang Y. Chinese Herbal Formulas: Treatment Principles and Composition Strategies. Churchill Livingstone Elsevier, 2010, p. 307.

Composition

Herb Amount % Role Function
Zhu Sha
toxic mark * in source; as printed: Zhu Sha (Cinnabaris)
15g 23.81% Jun (Chief) powerfully counters excess Heart-fire and sedates the Heart-shen
Huang Lian
as printed: Huang Lian (Coptidis rhizoma)
18g 28.57% Chen (Deputy) descends Heart-fire, relieves irritability
Gan Cao
also assistant protecting the Stomach from Zhu Sha and Huang Lian; as printed: Zhi Gan Cao (Glycyrrhizae radix preparata)
16g 25.4% Chen (Deputy) moderates Heart-Qi to stabilize the Shen; also protects the Stomach
Sheng Di Huang
as printed: Sheng Di Huang (Rehmanniae radix)
8g 12.7% Zuo (Assistant) nourishes Heart and Kidney Yin injured by fire; reduces Heart-fire
Dang Gui
also corrective assistant; as printed: Dang Gui (Angelicae sinensis radix)
6g 9.52% Zuo (Assistant) tonifies blood; prevents blood stagnation from cold, descending herbs

Energetics dose-weighted

The formula's overall nature, taste balance and channel reach, weighted by each herb's dose. Classical formulas often pair warm and cool herbs on purpose, so a net figure summarises the mix — it doesn't describe every herb in it.

Nature

Cold Cool Neutral Warm Hot

Net cool (-0.97)

From 100% of the weighed grams.

cold cool neutral warm

Grams by band: cold 41%, cool 24%, neutral 25%, warm 10%.

Taste

pungent sweet bitter
  • pungent 5%
  • sweet 60%
  • bitter 35%

From 100% of the weighed grams.

Channels reached

  • Heart 100%
  • Spleen 64%
  • Stomach 54%
  • Liver 51%
  • Large intestine 29%
  • Gallbladder 29%

Share of the grams entering each channel, from 100% of the weighed grams.

Dose-weighted from each herb's recorded nature, taste and channels (missing values are left out, never counted as neutral). It describes the composition — it is not a recommendation.

Compare side by side with Zhu Che Wan →

Preparation

Pill; Zhu Sha finely levigated in water and used as thin coating on pills

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Match score combines dosage-weighted composition (cosine, 70%) with shared-herb overlap (Jaccard, 30%).

Traditional formula information is for educational purposes only. Herbal formulas should be prescribed by a qualified practitioner — dosages and combinations are individualized and can interact with medications.

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