Wa Song

Star

Orostachys fimbriata (Turcz.) A.Berger

Not yet clinically reviewed

Pinyin: Wa Song
Chinese Dunce Cap

Traditionally used for

  • Cough & breathing
  • Bowel health
  • Menstrual & women's health
  • Skin

Cautions & contraindications

  • Kidney conditions
Limited evidence · 2 studies

☯ TCM Properties

Category: regulating blood
Temperature: cool
Taste: sour, bitter
Meridians: liver, lung, spleen
Functions:

Cools the Blood, stops bleeding, removes toxicity, invigorates the Blood and astringes wounds

Traditional Chinese Uses

Wa Song is the whole succulent herb of Orostachys fimbriata (Crassulaceae), a small stonecrop that colonises old tiled roofs. Sour and bitter with a neutral (traditionally cool) nature, it cools the Blood and stops bleeding, resolves toxicity, and astringes to close wounds, entering the Liver, Lung and Spleen channels. Classic indications are Blood-Heat bleeding — bloody dysentery, bleeding hemorrhoids, blood in the stool and uterine bleeding — and chronic non-healing sores and ulcers, for which the fresh herb is crushed and applied topically. It is also used for damp-heat and liver-heat complaints.

It is decocted or expressed for juice, with larger amounts used externally on the skin.

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Botanical Description

Wa Song is Orostachys fimbriata, a small biennial succulent of the stonecrop family Crassulaceae often colonising the tiles of old roofs and giving rise to its English name 'rooftop pine' or 'dunce cap'. In its first year the plant forms a dense, ground-hugging rosette of fleshy, glaucous, lance-shaped to spathulate leaves with finely fringed cartilaginous tips. In its second year the rosette elongates into a conspicuous tapering spike 10 to 30 centimetres tall, densely clothed in narrower leaves and terminating in a slender, conical or pagoda-shaped raceme of small, five-petalled, whitish to pinkish flowers; the plant flowers once, sets seed, and dies. The species favours dry, exposed sites: rock crevices, sandy slopes, walls, and roof tiles across northern and central China, Korea, and Japan.

Active Constituents

Epicatechin gallate

Flavan-3-ol gallate ester

Concentration: roughly 22% of the total flavonoids of an ethanolic extract of the dried aerial part (LC-MS profiling)

The single most abundant flavonoid identified in Orostachys fimbriata extracts. It is a strong radical scavenger and accounts for much of the antioxidant capacity measured for this herb; no human pharmacokinetic or efficacy data exist for it as delivered from this plant.

Quercetin

Flavonol aglycone

Concentration: roughly 7% of the total flavonoids of an ethanolic extract

Contributes antioxidant and anti-inflammatory activity to the extract. Quercetin and its 3-O-glucoside are the flavonols repeatedly reported from Wa Song in the Chinese materia medica literature.

Kaempferol

Flavonol aglycone

Concentration: roughly 3% of the total flavonoids of an ethanolic extract

Present both free and as glycosides (kaempferol-7-rhamnoside, kaempferol-3-glucoside-7-rhamnoside are listed for this species in Chinese materia medica sources). Anti-inflammatory and antioxidant in vitro.

Total flavonoids

Mixed flavonoid fraction

Concentration: about 160 mg per g of extract, i.e. more than half of the total polyphenol content of the extract

The flavonoid fraction, rather than any single marker, is what the modern literature credits with the antioxidant and anti-inflammatory actions attributed to Wa Song.

OFP (Orostachys fimbriata polysaccharide)

Homogeneous glucan (polysaccharide)

Concentration: purified fraction of about 6.2 kDa; composed only of glucose, with a 1,4-linked alpha-glucopyranosyl main chain

Suppressed LPS-induced nitric oxide, IL-1beta and IL-6 release from RAW264.7 macrophages in a concentration-dependent way and roughly halved xylene-induced ear swelling in mice. This is the best-characterised single constituent of the species and is notably smaller than the 30-50 kDa polysaccharide of the related Orostachys japonicus.

Oxalic acid

Dicarboxylic organic acid

Concentration: not quantified in peer-reviewed sources; Chinese accounts note the plant is used industrially as a raw material for oxalic acid extraction, and the drug's sour taste is attributed to it

Accounts for the sour taste recorded for Wa Song and is the most plausible basis for the toxicity that Chinese materia medica assigns to the herb. Oxalate precipitates calcium in the renal tubule, so an unquantified oxalate load is a real consideration for prolonged or high-dose internal use.

⚠ Drug Interactions

Orostachys japonicus (Korean Wa-song) supplied or cited in place of Orostachys fimbriata

Moderate Evidence: Established

The pinyin Wa Song is the Chinese Pharmacopoeia drug from the aerial parts of Orostachys fimbriata, but the identical Korean name Wa-song refers to Orostachys japonicus, and almost the entire modern pharmacology literature - the antiproliferative, anti-angiogenic and antimetastatic work, the acetaminophen hepatoprotection work, the macrophage immunostimulation work and the only published acute oral toxicity study - was done on O. japonicus. The two are separate accepted species in Plants of the World Online. Even the best-studied constituents differ: the O. fimbriata polysaccharide is a 6.2 kDa glucan whereas the O. japonicus polysaccharide is reported at 30-50 kDa.

Clinical note: Read any Wa Song claim against the binomial in the source paper. Do not transfer O. japonicus anticancer or hepatoprotective data to the O. fimbriata drug you are dispensing.

Calcium supplements, and use in calcium oxalate nephrolithiasis or chronic kidney disease

Theoretical Evidence: Theoretical

Wa Song is a Crassulaceae succulent whose sour taste is attributed to oxalic acid, and Chinese sources record it as a commercial source for oxalic acid extraction. Zhong Hua Ben Cao classifies the herb as toxic (you du) and cites animal work showing lethality at high dose. No clinical oxalate-loading study exists for this herb, so this is inference from the chemistry rather than a documented event.

Clinical note: Keep to the classical internal dose of about 5-15 g decocted, avoid prolonged courses, and avoid internal use altogether in stone formers or impaired renal function. External use (mashed fresh herb, or a wash) carries none of this concern.

Warm, tonifying or digestive prescriptions in Spleen and Stomach deficiency-cold

Minor Evidence: Possible

Wa Song is cool, sour and bitter, and the classical caution recorded for it (via Quanzhou Ben Cao and repeated in Zhong Hua Ben Cao) is that patients with Spleen and Stomach deficiency-cold should not take it. This is a pattern-level contraindication, not a pharmacokinetic interaction.

Clinical note: In a deficiency-cold presentation, either omit Wa Song or protect the middle with warming, harmonising herbs; watch for new loose stool after adding it.

Dosage

Form Amount Frequency Duration Population Notes
decoction, or powder/pills 3–9 g Daily — — 中国药典 2020 monograph 【瓦松】【用法与用量】3~9g。外用适量,研末涂敷患处。 【性味与归经】酸、苦,凉。归肝、肺、脾经。 — Matched to ChP by romanised drug name (pinyin 'Wa Song' → 瓦松); the romanisation is unique across all 649 ChP monographs, and the match was cross-checked against this record's own TCM temperature. Quoted verbatim.

Evidence Tier

Limited evidence · 2 studies

Recorded studies by study design, strongest design at the top. This is a study-design tier only, not a GRADE rating: it does not weigh risk of bias, consistency or precision.

Systematic review / meta-analysis

0

Randomized controlled trial

0

Other clinical trial

0

Observational / case report

0

Other / unclassified

0

Verified: design read from PubMed for a DOI that resolves to the cited paper Unverified: taken from the study's recorded description

Clinical Studies

Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

Datong Hu, Fan Su, Gan Yang, Jing Wang, Yingying Zhang (2021) Molecules in vitro

A homogeneous glucan of about 6.2 kDa (OFP) was purified from Orostachys fimbriata and its linkage pattern determined. In RAW264.7 macrophages OFP concentration-dependently inhibited LPS-driven nitric oxide, IL-1beta and IL-6 production, and in mice it reduced xylene-induced ear swelling by close to 50% at every dose tested. This is the clearest experimental support for the traditional anti-inflammatory and sore-healing use of the drug, and it is on the correct species.

Identification and Characterization of Major Flavonoids in Extracts from an Unexplored Medicinal Herb Orostachys fimbriata

Jeongho Lee, Hyerim Son, Kang Hyun Lee, Seunghee Kim, Ganzorig Myagmar, Soo-Yong Kim, Youngsang Chun, Hah Young Yoo (2022) Horticulturae in vitro

Solvent extracts of Orostachys fimbriata were profiled by LC-MS. Flavonoids made up more than half the total polyphenol content (about 160 mg per g extract), with epicatechin gallate, quercetin and kaempferol accounting for roughly 22%, 7% and 3% of the total flavonoids respectively. The authors describe the species as essentially unexplored chemically, which is a fair statement of how thin the O. fimbriata evidence base is compared with O. japonicus.

Historical Texts

Xin Xiu Ben Cao (Tang Ben Cao)

Tang dynasty
The herb enters the official materia medica in the state-issued Tang pharmacopoeia of 659 CE under the name Zuo Ye He Cao, the succulent that grows on old tiled roofs; the later name Wa Song (roof pine) is descriptive of the same habit.

Ben Cao Gang Mu

Ming dynasty
Li Shizhen keeps the herb under Zuo Ye He Cao and places it among the moss and lichen class, reflecting its roof-tile and wall habitat rather than any botanical affinity.

Zhong Hua Ben Cao

Modern (1999)
Records Wa Song as sour, bitter and cool, and explicitly as toxic (you du); functions given as cooling the Blood to stop bleeding, clearing Heat and resolving toxicity, and drying damp to heal sores. Internal dose 5-15 g decocted, or the fresh juice; externally applied mashed or as a wash. Cites the caution from Quanzhou Ben Cao that those with Spleen and Stomach deficiency-cold should not take it.

References

  1. Seon-Hee Kim, Deok-Seon Ryu, Hyeong-Seon Lee, Hye-Ryoung Shin, Ji-Hye Kwon, Dong-Seok Lee. Acute oral toxicity of the ethyl acetate fraction of Orostachys japonicus in mice . Pharmaceutical Biology (2014) [DOI]
  2. Datong Hu, Fan Su, Gan Yang, Jing Wang, Yingying Zhang. Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata . Molecules (2021) [DOI]

This information is for educational purposes only and is not intended to replace professional medical advice. Always consult a qualified healthcare provider before using any herbal remedy, especially if you are pregnant, nursing, or taking medications.

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