Rubia cordifolia

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Rubia cordifolia

Not yet clinically reviewed

Family: Rubiaceae Genus: Rubia Species: cordifolia

Synonyms: Galium cordifolium

Indian madderCommon madder茜草

Safety at a glance

No rule in our tables for this herb: pregnancy, breastfeeding, incompatible pairs (十八反 / 十九畏), herb–drug, dose ceiling. This is not a safety clearance.

Not graded — No toxicity grade is recorded. Most herbs in the catalogue carry none.

1 RCT on record

Western Herbalism Properties

Actions:
alterativeastringenthepatic

Botanical Description

Rubia cordifolia, commonly known as Indian madder, manjistha, or in Chinese medicine as qian cao, is a climbing or scrambling herbaceous perennial in the family Rubiaceae, widely distributed across temperate and tropical Asia from the Himalayas to Japan, and extending into parts of Africa. The plant produces slender, four-angled, often prickly stems that climb to 1.5 metres or more by means of small recurved bristles on the angles. Leaves are arranged in whorls of four or more, ovate to cordate, 2 to 9 cm long, with conspicuously cordate bases, palmately three- to five-veined, and rough or bristly margins. The inflorescence is an open terminal or axillary cyme of tiny five-lobed, greenish-white to pale yellow tubular flowers. Fruits are small, fleshy, two-lobed berries that ripen from green through red to glossy black. The most distinctive feature is the long cylindrical reddish to deep red-brown perennial root, which yields the historically important madder dye and is the principal medicinal part used in both Ayurveda and traditional Chinese medicine.

Native Region: Afghanistan, Amur, Angola, Assam, Bangladesh, Borneo, Burundi, Buryatiya, Cape Provinces, China North-Central, China South-Central, China Southeast, Chita, East Himalaya, Ethiopia, Free State, Greece, India, Inner Mongolia, Japan, Jawa, Kenya, Khabarovsk, Korea, KwaZulu-Natal, Malawi, Malaya, Mongolia, Mozambique, Myanmar, Nepal, Northern Provinces, Pakistan, Primorye, Qinghai, Rwanda, Somalia, Sri Lanka, Sudan, Sumatera, Swaziland, Taiwan, Tanzania, Tibet, Uganda, Vietnam, West Himalaya, Zambia, Zaïre, Zimbabwe

Dosage Calculator

⚖ Dosage Calculator

A weight-based mathematical estimate for Rubia cordifolia. Not a prescription.

Evidence Tier

1 RCT on record

Recorded studies by study design, strongest design at the top. This is a study-design tier only, not a GRADE rating: it does not weigh risk of bias, consistency or precision.

Systematic review / meta-analysis

0

Other clinical trial

0

Observational / case report

0

In vitro / animal

0

Other / unclassified

0

Verified: design read from PubMed for a DOI that resolves to the cited paper Unverified: taken from the study's recorded description

Clinical Studies

Modulatory Effects of Triphala and Manjistha Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study

Christine T. Peterson; Aunna Pourang; Simran Dhaliwal; Jordan N. Kohn; Sasha Uchitel; Harjot Singh; Paul J. Mills; Scott N. Peterson; Raja K. Sivamani (2020) The Journal of Alternative and Complementary Medicine RCT Verified: Randomized controlled trial

The only controlled human trial of Rubia cordifolia as a single herb. Thirty-one healthy adults were randomised to 2,000 mg/day of manjistha (Rubia cordifolia), triphala, or placebo for four weeks, with faecal 16S rRNA profiling at baseline and week 4. Responses were highly individual and no taxon changed uniformly; both herb arms showed a trend to a lower Firmicutes:Bacteroidetes ratio, higher relative abundance of Akkermansia muciniphila, and reduced Rikenellaceae (chiefly Alistipes spp.). It is a microbiome pilot, not an efficacy trial, but it establishes that 2 g/day of the powdered drug was tolerated for four weeks in healthy adults (ClinicalTrials.gov NCT03477825).

Historical Texts

Charaka Samhita, Sutrasthana 4 (Varnya Mahakashaya)

Ayurvedic classical period, compiled c. 1st-2nd century CE
Manjishtha is named among the ten varnya drugs, those that improve the complexion by acting on the tissue rather than the surface. This Ayurvedic identity of the drug, alongside its use as a raktashodhaka (blood-cleansing) agent, is the tradition in which Rubia cordifolia is most heavily used outside China, and is distinct from the Chinese Qian Cao Gen indication of cooling blood and stopping bleeding.

Bhavaprakasha Nighantu, Haritakyadi Varga

16th century CE, India
Gives the standard Ayurvedic property account of Manjishtha: kashaya-tikta-madhura rasa, ushna virya, and indications in kushtha (skin disease), visha (toxicity) and raktavikara (blood disorders).

This information is for educational purposes only and is not intended to replace professional medical advice. Always consult a qualified healthcare provider before using any herbal remedy, especially if you are pregnant, nursing, or taking medications.

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