St John's wort

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Hypericum perforatum L.

Not yet clinically reviewed

Family: Hypericaceae Genus: Hypericum Species: perforatum

St John's wortCommon St John's wortGuan Ye Jin Si Tao贯叶金丝桃Guan Ye Lian Qiao贯叶连翘

Cautions & contraindications

Before surgery

Traditional use

⚠ Drug Interactions

Serotonergic antidepressants (SSRIs, SNRIs, MAOIs)

Major Evidence: Reported

Additive serotonergic activity

Clinical note: Only with clinician supervision (Mayo Clinic; 2009 review, PubMed 19859815).

Oral contraceptives

Major Evidence: Reported

Enzyme induction (cytochrome P450 and P-glycoprotein)

Clinical note: Unwanted pregnancies reported in women taking oral contraceptives (2009 review, PubMed 19859815).

Cyclosporin

Major Evidence: Reported

Enzyme induction (cytochrome P450 and P-glycoprotein)

Clinical note: Relevant in transplant and immunosuppressed patients (2009 review, PubMed 19859815).

Antiretrovirals (e.g. indinavir, nevirapine) and anticancer drugs (e.g. imatinib, irinotecan)

Major Evidence: Reported

Enzyme induction (cytochrome P450 and P-glycoprotein)

Clinical note: Clinically significant interactions reported (2008 and 2009 reviews).

Alprazolam

Moderate Evidence: Reported

Not specified in source

Clinical note: Noted by Mayo Clinic.

Dosage Calculator

⚖ Dosage Calculator

A weight-based mathematical estimate for St John's wort. Not a prescription.

⚠ Safety & Contraindications

Before surgery

Side Effects

Diarrhea, constipation, upset stomach, dry mouth, tiredness, trouble sleeping, headache. Increased sun sensitivity (Mayo Clinic).

Safety Warnings

Check with a clinician before use if taking prescription medicines, birth control, or planning surgery (Mayo Clinic). Interactions can be serious.

References

This information is for educational purposes only and is not intended to replace professional medical advice. Always consult a qualified healthcare provider before using any herbal remedy, especially if you are pregnant, nursing, or taking medications.

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