Gua Di San

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瓜蒂散 (Melon Pedicle Powder)

Source: Shang Han Lun — Zhang Zhong-Jing (Eastern Han, c. 220)

Last updated October 1, 2026

Not yet clinically reviewed

acute poisoningmaniahepatitisjaundice

Description

Gua Di San (Melon Pedicle Powder), from the Shang Han Lun (Discussion of Cold-Induced Disorders) by Zhang Zhong-Jing.

Actions: Induces vomiting of phlegm or stagnant food.

Presentation: Phlegm or food stagnation in the chest and epigastrium: chest or epigastric distention and hardness, feelings of discomfort, a feeling of qi rising to the throat causing difficulty in breathing, restlessness, and a slightly superficial pulse at the cun position.

Cautions:

  • Gua Di is toxic and injures qi and Stomach; contraindicated with Spleen and Stomach deficiency
  • Contraindicated without stagnant phlegm in the chest, or when stagnant food has passed to the intestines
  • Only for acute excess conditions; extreme caution in children, elderly, postpartum blood deficiency, and dizziness/palpitations from qi and blood deficiency
  • Discontinue once effective; no prolonged use
  • Do not use to induce vomiting of corrosive substances

Toxicology: Small doses: no significant change in respiration, blood pressure or heart rate. Large doses: irregular respiration, lowered blood pressure and heart rate, eventually respiratory collapse. One fatality 8 h after 30g Gua Di + 15g Chi Xiao Dou on an empty stomach; another fatality from GI bleeding the same day (dose unknown). Overdose: discontinue; persistent vomiting relieved with 0.03-0.06g She Xiang or 0.3-0.6g Ding Xiang.

Source: Chen JK, Chen TT. Chinese Herbal Formulas and Applications: Pharmacological Effects & Clinical Research. Art of Medicine Press, 2009, p. 1311.

Composition

Herb Amount % Role Function
Gua Di
dose printed as 1-2g; as printed: Gua Di (Pedicellus Cucumeris) [1-2g]
g — induces vomiting of phlegm and stagnant food
Chi Xiao Dou
dose printed as 1-2g; as printed: Chi Xiao Dou (Semen Phaseoli) [1-2g]
g — with Gua Di expels phlegm and relieves distention and hardness

Dui Yao — Core Herb Pairs

The classical two-herb combinations at the heart of this formula, as recorded on the herbs' own pages — each pair has an action neither herb has alone.

Chi Xiao Dou赤小豆 + Gua Di瓜蒂

Bitter emetic action combined with the sour-sweet bean, which together induce vomiting to expel phlegm or food lodged in the chest and upper stomach.

Phlegm or undigested food obstructing the chest in robust patients. Gua Di is toxic; discontinue once vomiting occurs; contraindicated in weak patients, the elderly and pregnancy.

Preparation

Gua Di simmered until yellow. Grind equal amounts of both into fine powder; take 1 spoonful (1-3g) with a warm strained decoction of 6-9g Dan Dou Chi. Increase slightly if no vomiting; gag reflex may be used. Stop once vomiting occurs.

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Traditional formula information is for educational purposes only. Herbal formulas should be prescribed by a qualified practitioner — dosages and combinations are individualized and can interact with medications.

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